clinical research

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  • Cancer Breakthroughs
  • What is Clinical Research?
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Clinicla Research & Fundings > Cancer Breakthroughs

Cancer Breakthroughs

Targeted cancer therapy

Carcinoma – Cancer with tumor made of epithelial (skin) cells.Immunotherapy (Checkpoint blockade therapy)

The immune response is

Antibody drugs target specific receptors

Adopted Cell Transfer - Immunotherapy using adopted T-cell therapy

● T-cells are lymphocytes (white blood cells).

● Basic process – T cells are extracted from patient's blood, genetically engineered to exhibit Chimeric Antigen Receptors (CAR) towards antigens found on tumor cells. With those CARs, the T-cells will be able to recognize and target those cancer cells. The engineered T-cells are then lab cultured and then reinserted into the body.

These T-cells can also be modified to be more resistant to tumor-derived immunosuppression that would prevent unmodified lymphocytes from attacking the tumor cells, as well as to be more vulnerable to immunosuppressant drugs that can kill the T-cells if they become out of control.

Research is still in early stages

One study administered the ACT treatment to 14 patients with two types of B cell lymphoma. Most of these patients had proven to have chemotherapy refractory (resistant or nonresponsive to chemotherapy) malignancies. Out of 14 patients, 5 had complete remissions (no more cancer) of up to 19 months and 6 had partial remissions (one up to 20 months).

● ACT can also be used to treat carcinomas and solid tumors.

● Research into this type of therapy is still at early stages, with existing research being small scale and the results still tentative. More research is needed to determine whether ACT can become another pillar of cancer treatment like surgery, radiotherapy, or chemotherapy.

Kershaw, M. H., Westwood, J. A., & Darcy, P. K. (2013). Gene-engineered T cells for cancer therapy. Nature Reviews Cancer, 13(8), 525-541.